Charcot Marie Tooth disease (CMT)


Charcot Marie Tooth (CMT) is an inherited neurological disease characterized by the gradual degeneration of nerves which starts in the hands and feet and results in progressive numbness, muscle weakness and loss of function. Type 1E involves the usual CMT symptoms as well as deafness. There are over 40 types of Charcot-Marie-Tooth disease. Charcot-Marie-Tooth disease is the most common inherited disorder that involves the peripheral nerves, affecting an estimated 150,000 people in the United States. It occurs in populations worldwide with a prevalence of about 1 in 2,500 individuals.

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Symptoms of Charcot-Marie-Tooth disease typically appear in adolescence or early adulthood, but this condition can develop in midlife too. Symptoms usually begin in your feet and legs, but they may eventually affect your hands and arms. The severity of symptoms can vary greatly from person to person. This is true even among family members


Signs and symptoms of Charcot-Marie-Tooth disease may include:

  • weakness in your legs, ankles, feet and hand
  • loss of muscle bulk in legs and feet
  • high foot arches
  • curled toes (hammertoes)
  • decreased ability to run
  • difficulty lifting your foot at the ankle (footdrop)
  • awkward or higher than normal step (gait)
  • frequent tripping or falling
  • decreased sensation or a loss of feeling in your legs and feet
  • foot drop
  • foot deformity
  • loss of lower leg muscle
  • numbness in the foot or leg
  • balance problems
  • wasted hand and foot muscles
  • hand and Foot pain
  • sensory loss
  • deafness
  • unusual gait
  • claw hands

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