Study Through Imaging of Visceral Lymphoid Organs in Patients With SCID Who Have Recieved Bone Marrow Allograft

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Brief Title

Study Through Imaging of Visceral Lymphoid Organs in Patients With SCID Who Have Recieved Bone Marrow Allograft

Official Title

Study Through Imaging of Mediastinal and Abdominopelvic Secondary Lymphoid Organs (Lymph Nodes) in Patients With Severe Combined Immunodeficiencies (SCID) Who Have Recieved Bone Narrow Allograft

Brief Summary

      To investigate the presence of seconday of lymphoid organs in patients who underwent
      allogenic hematopoietic stem cell transplantation 15 to 45 years ago.

      The goal aims to assess the development of seconday lymphoid organs given the fact that the
      absence of myeloablation these patients present a split chimerism between T lymphocytes and
      the other leucocytes. Thus, they may not be able to generate seconday lymphoid organs.
      Practically, whole body MRI is being used to visualise and quantify both mediastinal and
      intraabdominal lymph nodes. Delta will be compared with those obtained in healthy age-matched
      individuals. It is scheduled to include 15 patients and 15 controls.
    



Study Type

Observational


Primary Outcome

Size of mediastinal and intraabdominal lymph nodes


Condition

Severe Combined Immunodeficiency


Study Arms / Comparison Groups

 Study group
Description:  15 adult patients who underwent allogenic hematopoietic stem cell transplantation (HSCT) for severe combined immunodeficieny 15 to 45 years ago

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information



Estimated Enrollment

30

Start Date

February 1, 2020

Completion Date

February 1, 2021

Primary Completion Date

February 1, 2021

Eligibility Criteria

        Inclusion Criteria:

          -  Patients with SCID transplanted 15-45 years ago

        Exclusion Criteria:

          -  None
      

Gender

All

Ages

18 Years - N/A

Accepts Healthy Volunteers

Accepts Healthy Volunteers

Contacts

, , 



Administrative Informations


NCT ID

NCT04246840

Organization ID

AARIP-01


Responsible Party

Sponsor

Study Sponsor

Association Pour l'Aide a la Recherche en Immunologie Pediatrique


Study Sponsor

, , 


Verification Date

January 2020