Efficacy of Type-5 Phosphodiesterase Inhibitors in Primary and Secondary Pulmonary Hypertension

Brief Title

Efficacy of Type-5 Phosphodiesterase Inhibitors in Primary and Secondary Pulmonary Hypertension

Official Title

Clinical Efficacy of Type-5 Phosphodiesterase Inhibitors (Sildenafil and Vadenafil) in Primary and Secondary Pulmonary Hypertension

Brief Summary

      The aim of this trial is to evaluate the efficacy of type-5 phosphodiesterase inhibitors
      (sildenafil) in primary and secondary pulmonary hypertension
    

Detailed Description

      Patients with primary and secondary pulmonary hypertension will be recruited and admitted to
      the ICUs of the National Taiwan University Hospital. Each patient will undergo Swan-Ganz
      catheterization and hemodynamic monitoring during administration of sildenafil. Efficacy of
      inhaled NO and Iloprost will also be compared.
    


Study Type

Interventional


Primary Outcome

mean pulmonary artery pressure

Secondary Outcome

 cardiac output

Condition

Primary and Secondary Pulmonary Hypertension

Intervention

type-5 phosphodiesterase Inhibitor (Sildenafil)


Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Drug

Estimated Enrollment

20

Start Date

November 2002

Completion Date

May 2005


Eligibility Criteria

        Inclusion Criteria:Patients with primary and secondary pulmonary arterial hypertension

        -

        Exclusion Criteria:Unstable patients or patients with allergy to sildenafil
      

Gender

All

Ages

12 Years - N/A

Accepts Healthy Volunteers

No

Contacts

Ping-Hung Kuo, MD, , 

Location Countries

Taiwan

Location Countries

Taiwan

Administrative Informations


NCT ID

NCT00155714

Organization ID

9100017321



Study Sponsor

National Taiwan University Hospital


Study Sponsor

Ping-Hung Kuo, MD, Principal Investigator, National Taiwan University Hospital


Verification Date

January 2010