Determinants of Disease Severity in Amyotrophic Lateral Sclerosis
I. Determine specific clinical features, molecular abnormalities, and laboratory-based
biological markers of free radical stress that are associated with amyotrophic lateral
sclerosis and influence disease severity.
PROTOCOL OUTLINE: This is a screening and diagnostic study. Blood and urine samples are
collected from patients every 2 months for 1 year. All samples are evaluated for measures of
free radical damage and levels of the body's own antioxidant activity.
Amyotrophic Lateral Sclerosis
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
PROTOCOL ENTRY CRITERIA:
--Disease Characteristics-- Clinically diagnosed probable or definite, sporadic or familial
amyotrophic lateral sclerosis
--Patient Characteristics-- Pulmonary: No artificial ventilation required Other: No other
neurodegenerative diseases No concurrent or history of unstable medical illness
18 Years - N/A
Accepts Healthy Volunteers
Merit E. Cudkowicz, ,
National Institute of Neurological Disorders and Stroke (NINDS)
Massachusetts General Hospital
Merit E. Cudkowicz, Study Chair, Massachusetts General Hospital