Determinants of Disease Severity in Amyotrophic Lateral Sclerosis

Brief Title

Determinants of Disease Severity in Amyotrophic Lateral Sclerosis


Brief Summary

      OBJECTIVES:

      I. Determine specific clinical features, molecular abnormalities, and laboratory-based
      biological markers of free radical stress that are associated with amyotrophic lateral
      sclerosis and influence disease severity.
    

Detailed Description

      PROTOCOL OUTLINE: This is a screening and diagnostic study. Blood and urine samples are
      collected from patients every 2 months for 1 year. All samples are evaluated for measures of
      free radical damage and levels of the body's own antioxidant activity.
    


Study Type

Observational




Condition

Amyotrophic Lateral Sclerosis



Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information



Estimated Enrollment

75

Start Date

March 1998



Eligibility Criteria

        PROTOCOL ENTRY CRITERIA:

        --Disease Characteristics-- Clinically diagnosed probable or definite, sporadic or familial
        amyotrophic lateral sclerosis

        --Patient Characteristics-- Pulmonary: No artificial ventilation required Other: No other
        neurodegenerative diseases No concurrent or history of unstable medical illness
      

Gender

All

Ages

18 Years - N/A

Accepts Healthy Volunteers

No

Contacts

Merit E. Cudkowicz, , 



Administrative Informations


NCT ID

NCT00004457

Organization ID

199/13650

Secondary IDs

MGH-97-7231


Study Sponsor

National Institute of Neurological Disorders and Stroke (NINDS)

Collaborators

 Massachusetts General Hospital

Study Sponsor

Merit E. Cudkowicz, Study Chair, Massachusetts General Hospital


Verification Date

January 2001