Change in Peripheral Oxygen Saturation by Using Different Breathing Procedures in High Altitude

Learn more about:

Brief Title

Change in Peripheral Oxygen Saturation by Using Different Breathing Procedures in High Altitude


Brief Summary

      In this investigation the researchers explore whether different types of breathing procedures
      can improve the peripheral oxygen saturation to reduce the risk of becoming a acute mountain
      sickness or a high altitude pulmonary edema.
    

Detailed Description

      Acute mountain sickness (AMS) is a pathological effect of high altitude on humans caused by
      acute exposure to low partial pressure of oxygen at high altitude. It commonly occurs above
      2500 meters of altitude. AMS appears as a collection of nonspecific symptoms acquired at high
      altitude or in low air pressure resembling a case of "flu, carbon monoxide poisoning, or a
      hangover".

      It is caused by a drop in pressure and lowering partial pressure of oxygen during increasing
      altitude. The direct consequence of those changes is a hypoxic pulmonary vasoconstriction
      (Euler-Lijestrand-mechanism). In addition a rise in pulmonary blood pressure (Hypertonia) can
      occur so that there is a higher risk of developing a high altitude pulmonary edema (HAPE).

      In this investigation the investigators are exploring whether different types of breathing
      procedures can improve the peripheral oxygen saturation. We are comparing breathing with no
      regulation with two different procedures of hyperventilation during trekking in different
      altitudes. Procedure 1 (hyperventilation 1) describes inhalation during one step and
      exhalation during the next step. Procedure 2 (hyperventilation 2) describes inhalation and
      exhalation during one step.

      The effect of the different breathing procedures can be quantified measuring the peripheral
      oxygen saturation. In addition the investigators are comparing the breathing rate and the
      minute ventilation as well as the expiratory end-tidal CO2-partial pressure of the three
      different breathing procedures.

      Furthermore, the investigators are examining the ability to concentrate in order to quantify
      the effect of AMS on organ functions.
    


Study Type

Interventional


Primary Outcome

change of peripheral oxygen saturation

Secondary Outcome

 change of breathing parameters

Condition

Acute Mountain Sickness

Intervention

Breathing procedure 1

Study Arms / Comparison Groups

 Breathing procedure 1
Description:  Walking with breathing procedure "1".

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Other

Estimated Enrollment

30

Start Date

July 2011

Completion Date

November 2011

Primary Completion Date

October 2011

Eligibility Criteria

        Exclusion Criteria:

          -  acute clinically significant inter-current diseases
      

Gender

All

Ages

18 Years - N/A

Accepts Healthy Volunteers

Accepts Healthy Volunteers

Contacts

Gabor Szalay, Dr. med., , 

Location Countries

Germany

Location Countries

Germany

Administrative Informations


NCT ID

NCT01468194

Organization ID

Gi-04-2011


Responsible Party

Principal Investigator

Study Sponsor

University of Giessen

Collaborators

 MVZ für Laboratoriumsmedizin Koblenz

Study Sponsor

Gabor Szalay, Dr. med., Principal Investigator, Trauma surgery - University hospital Giessen


Verification Date

November 2011