Bortezomib With Chemotherapy for Relapsed Pediatric Acute Lymphoblastic Leukemia (ALL)

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Brief Title

Bortezomib With Chemotherapy for Relapsed Pediatric Acute Lymphoblastic Leukemia (ALL)

Official Title

A Study of Bortezomib With Chemotherapy for Relapsed/Refractory Acute Lymphoblastic Leukemia

Brief Summary

      This is a Phase I/II study of a drug called bortezomib given in combination with chemotherapy
      drugs used to treat acute lymphoblastic leukemia (ALL) that has come back (recurred).
      Bortezomib is a drug that has been approved by the Food and Drug Administration (FDA) for
      treating adults with multiple myeloma which is a type of blood cancer. Bortezomib has been
      shown to cause cancer cells to die in studies done on animals (mice). Studies have been done
      that have shown that some adults and children with cancer have shown a response to bortezomib
      when it is used alone. Studies have also been done in adults to evaluate the dose of
      bortezomib that can be safely given in combination with other chemotherapy drugs.
    

Detailed Description

      All patients will receive 1 course of chemotherapy unless medical complications prevent the
      administration of some of the drugs. Treatment will last about 1 month.

      Treatment on this study will consist of a combination of 7 anti-cancer medications. The 7
      anti-cancer medicines are bortezomib, vincristine, dexamethasone, PEG-asparaginase,
      doxorubicin, cytarabine (Ara-C), and methotrexate (MTX).

      If you are in the Phase I portion of this study, you will be given an assigned dose of
      bortezomib. The dose of bortezomib will be based on doses given in previous studies done with
      adults and children. At each dose level of bortezomib, between 3 and 6 children will receive
      bortezomib in combination with chemotherapy. If the side effects are not too severe, the next
      group of children will receive a higher dose. The dose will continue to be increased until we
      find the dose that causes serious side effects. Your dose of bortezomib will not be
      increased. If you have bad side effects, your dose may be decreased.

      The dose used during the Phase 2 part of this study will be determined by the outcome of the
      Phase I study. The highest dose used in Phase I that was tolerated without serious side
      effects will be the one used in Phase 2.
    

Study Phase

Phase 1/Phase 2

Study Type

Interventional


Primary Outcome

Occurrence of a Dose-Limiting Toxicity (Phase 1)


Condition

Acute Lymphoblastic Leukemia

Intervention

Bortezomib

Study Arms / Comparison Groups

 Ph 1 Dose Escalation
Description:  Intervention: Bortezomib with chemotherapy (dexamethasone, PEG-asparaginase, doxorubicin, cytarabine, methotrexate, and vincristine) and Triple IT therapy for patients who are CNS 2 or 3 at study entry. 3+3 escalation design.

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Drug

Estimated Enrollment

31

Start Date

August 4, 2006

Completion Date

February 26, 2011

Primary Completion Date

February 26, 2011

Eligibility Criteria

        Inclusion Criteria

        The eligibility criteria listed below are interpreted literally and cannot be waived.

          1. Age Patients must be < 21 years of age when originally diagnosed with ALL. Patient
             must be > 1 year of age at study entry.

          2. Diagnosis Patients must have relapsed or refractory ALL with a M3 marrow (marrow
             blasts >25%). Patients with CNS I, II or III or testicular disease are eligible.

          3. Performance Level Karnofsky > 50% for patients > 10 years of age and Lansky > 50% for
             patients < 10 years of age.

          4. Prior Therapy Patients must have fully recovered from the acute toxic effects of all
             prior chemotherapy, immunotherapy, or radiotherapy prior to entering this study.

               1. Prior anthracycline exposure: Patients must have less than 400mg/m2 lifetime
                  exposure of anthracycline chemotherapy.

               2. Stem Cell Transplant (SCT): Patients are eligible after allogeneic stem cell
                  transplant as long as patients are not actively being treated for
                  graft-versus-host-disease (GvHD).

               3. Patients should not have received previous therapy using bortezomib (Velcdade® or
                  PS-341).

               4. During the phase I portion of the trial, there is no limit on the number of prior
                  treatment regimens. Patients with persistent disease after an induction attempt
                  are eligible.

               5. During the phase II portion of the trial, patients must have had two or more
                  prior therapeutic attempts defined as:

                    -  Persistent initial disease after two induction attempts, or

                    -  Relapse after one-reinduction attempt (2nd relapse), or

                    -  Persistent disease after first relapse and initial re-induction attempt

                  (Patients in first relapse are not eligible for the phase II portion of the
                  study)

               6. During the phase II portion of the trial, patients must have no more than 3 prior
                  therapeutic attempts and it must be at least 3 months since the last treatment
                  with a "VPLD" induction/re-induction regimen.

          5. Reproductive Function

               1. Female patients of childbearing potential must have a negative urine or serum
                  pregnancy test confirmed prior to enrollment.

               2. Female patients with infants must agree not to breastfeed their infants while on
                  this study.

               3. Male and female patients of child-bearing potential must agree to use an
                  effective method of contraception approved by the investigator during the study.

        Exclusion Criteria

          1. Drug Allergies

             Patients will be excluded if they have allergies to the following:

               -  Asparaginase products

               -  Boron

               -  Mannitol

          2. Renal Function Patients will be excluded if their serum creatinine is > 2 x the upper
             limit of normal for age at the institution's laboratory.

          3. Liver/Pancreatic Function

               1. Direct bilirubin > 1.5x the institutional ULN for age. A total bilirubin result
                  that is less than 1.5 times the institutional ULN for age may be used for
                  eligibility if a direct bilirubin result is not available.

               2. SGPT (ALT) > 4 x institutional ULN

               3. Grade 3 or greater pancreatitis as defined by the CTCAE v3.0

               4. History of any L-asparaginase induced pancreatitis

               5. Amylase or Lipase > 2 x institutional ULN

          4. Cardiac Function Patients will be excluded if their shortening fraction by
             echocardiogram is less than 30%.

          5. Patients with Down Syndrome are excluded.

          6. Infection

               -  Patients will be excluded if they have an active uncontrolled infection.

               -  Patients will be excluded if they have had a positive culture within 2 weeks of
                  study entry.

          7. Patients with grade 2 or greater motor or sensory neuropathy per CTC 3.0 criteria.

          8. Patients planning on receiving other investigational agents while on this study. (An
             investigational agent is defined as any drug not currently approved for use in
             humans.)

          9. Patients planning on receiving other anti-cancer therapies while on this study.
             Hydroxyurea for cyto-reduction is allowed prior to the start of therapy.

         10. Patients who, in the opinion of the investigator, may not be able to comply with the
             safety monitoring requirements of the study.

         11. Patients who have started protocol therapy prior to enrollment. Patient may still
             enroll if IT therapy was given within 72 hours of study enrollment as part of the
             diagnostic lumbar procedure.
      

Gender

All

Ages

1 Year - 21 Years

Accepts Healthy Volunteers

No

Contacts

Yoav Messinger, MD, , 

Location Countries

Australia

Location Countries

Australia

Administrative Informations


NCT ID

NCT00440726

Organization ID

T2005-003


Responsible Party

Sponsor

Study Sponsor

Therapeutic Advances in Childhood Leukemia Consortium


Study Sponsor

Yoav Messinger, MD, Study Chair, Children's Hospital and Clinics of Minnesota


Verification Date

February 2020